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CORTI OFF+ is a dietary supplement based on choline VitaCholine™, theanine, ashwagandha KSM-66® extract, phosphatidylserine and vitamin B6, intended to support the body during periods of severe psycho-physical stress and to help stem the negative effects caused by excessive levels of circulating cortisol.

Cortisol is a hormone that mediates the response to stress and modulates the regulation of the sleep-wake cycle. Cortisol secretion by the body is generally high in the morning and low in the evening and allows the body to have enough energy at its disposal.

Cortisol is not necessarily a harmful substance, but an excessive concentration of this hormone - particularly if it is present for long periods - may adversely affect protein synthesis, muscle mass, sleep quality and immune response, or may induce insulin resistance and endothelial dysfunction. The increase in cortisol secretion levels is mainly due to the increase in the stress stimuli to which the body is subjected. Intense and prolonged exercise, for example, is perceived by the body as a form of stress and stimulates the synthesis of cortisol. For this reason, athletes who practise endurance sports, or who train with high frequency and do not allow themselves adequate rest, are more exposed to high cortisol levels.

The formulation of CORTI OFF+ carries substances that help to deal with periods of particular psycho-physical stress and to limit the increase in cortisol levels in response to stressful stimuli:

  • Vitacholine® choline: choline is an essential substance for the synthesis of acetylcholine, an important neurotransmitter of the nervous system. Choline supplementation increases the acetylcholine reserves in the brain, promoting brain processes such as memory and concentration, which are affected by mental and physical fatigue caused by stress;
  • L-theanine: L-theanine is an amino acid that supports mental well-being. Theanine, in fact, promotes relaxation without adversely affecting cognitive For example, its use reduces stress and, at the same time, increases attention and improves the quality of sleep, which can be affected by moments of severe psycho-physical stress;
  • ashwagandha KSM66® extract: ashwagandha root has a tonic-adaptogenic effect, promotes physical and mental wellbeing, improves memory and concentration and helps to reduce anxiety and stress. In addition, several studies have demonstrated the ability of the KSM66® extract to lower the circulating cortisol levels;
  • phosphatidylserine: phosphatidylserine is a phospholipid and an important component of cell membranes, particularly in the nervous system. Phosphatidylserine regulates the permeability and integrity of nerve cell membranes. Moreover, it is involved in the transduction of signals and the excitability of neurons. By virtue of these functions, taking phosphatidylserine helps to increase concentration and memory. In addition, it is used to limit cortisol levels in cases of high physical stress;
  • vitamin B6: Vitamin B6 contributes to normal energy metabolism, the reduction of tiredness and fatigue and the regulation of hormonal


Take 2 capsules per day, preferably after the main meals.


VitaCholine™ (choline bitartrate), L-theanine, capsule (glazing agent: hydroxypropyl methylcellulose; colour: calcium carbonate), KSM-66® Ashwagandha Root Extract-Vegan [ashwagandha (Withania somnifera (L.) Dunal) root d.e. tit. 5% total withanolides), bulking agent: cellulose; soy phospholipids powder (of which 70% phosphatidylserine), anti-caking agents: magnesium salts of fatty acids, silicon dioxide; pyridoxine hydrochloride (vitamin B6).