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Creatine is a molecule produced by the body from glycine, arginine and S-adenosyl-methionine. In resting conditions, creatine is converted into phosphocreatine (PCr) , a compound containing a phosphate group. During muscle activity, the phosphate group is transferred to ADP to regenerate ATP, the molecule that provides the energy needed to carry out a number of body's cellular reactions. The role of creatine in energy production is therefore particularly relevant in conditions of high-energy demands, as in the case of repetitive and short-term intense physical activity.


The use of creatine-based products induces an increase in the concentration of creatine and phosphocreatine in the skeletal muscle at rest, allowing to maintain high levels of ATP during physical exertion and to increase the synthesis of phosphocreatine in the recovery phases. However, supplementation with high intake of creatine results in an increased urinary excretion of this substance, because the muscle uptake of creatine is mediated by an active transport mechanism that goes towards saturation: when transporters are saturated, the excess of creatine is removed with urine or metabolized to creatinine. Thus, creatine is no longer usable.

CREA PHASE+ is a supplement developed with the patented CREAFAST® formula, that allows to release creatine in a gradual and controlled way. The formulation of CREA PHASE+

optimizes creatine muscle uptake, ensuring that the entire dose is absorbed by the muscle, avoiding its partial renal elimination.

The patented CREAFAST® formula is characterized by a biphasic formulation in enteric-coated tablets, consisting of two components:

  • creatine monohydrate in free form, with fast release and immediately usable
  • creatine monohydrate supported on magnesium hydroxide, with delayed release

The combination of creatine with magnesium hydroxide allows to modulate the release of creatine in the intestine, thus preventing the supersaturation of the transporters that favour absorption. In this way, assimilation of the entire dose of creatine is guaranteed and a constant and effective concentration of creatine in the blood is assured for 5-6 hours.

The optimization of creatine assimilation in the intestine and the maintenance of its effective plasma concentration allow to deliver the entire dose to the skeletal muscle cells, maximising muscle uptake. Compared to traditional forms of creatine, CREA PHASE+ formula improves the retention of creatine by the muscle fibres and guarantees an increase in the supply of creatine to muscles.

Moreover, the CREAFAST® technology in CREA PHASE+ avoids the onset of gastrointestinal disorders and other side effects (such as kidney stress and overwork , high urinary excretion, formation of potentially harmful metabolites) related to an excess of unabsorbed creatine.

CREA PHASE+, formulated with CREAFAST®, is the controlled release creatine supplement that delivers the entire dose to the site of action, resulting in an advantage in terms of performance, safety profile and practicality.


As needed:

  • 3 tablets once a day in one single administration, for a total of 3 g of creatine;
  • one serving, corresponding to 2 tablets, three times per day at 6 hours intervals for a total of 6 g of creatine. In this case, do not exceed thirty days of oral supplementation


Creatine monohydrate, thickener: magnesium hydroxide; bulking agents: cellulose microcrystalline, hydroxypropyl cellulose; anti-caking agents: magnesium salts of fatty acids, silicon dioxide; coating (glazing agents: hydroxypropyl methyl cellulose, talc; medium chain triglyerides, colours: titanium dioxide, sunset yellow FCF*, quinoline yellow*, ponceau 4R*). *May have an adverse effect on activity and attention in children.