Slow-onset muscle pain, called DOMS from the English Delayed Onset Muscle Soreness, is the muscle soreness felt from 24 to 48 hours after aerobic, anaerobic or mixed exercise. Recent investigations have now shown that DOMS is not caused by lactic acid, as it was mistakenly thought, but is triggered by various factors, linked to the muscle damage caused by training. In practice it is due to microlesions of the muscular and connective tissue that cause acute inflammation, causing the recall of pro-inflammatory cytokines, chemokines, lymphocytes and macrophages. These substances cause a series of chain reactions and the formation of catabolism waste products, which manifest themselves with a sensation of pain, in particular during movement and palpation. Metabolites also increase vascular permeability and determine a mobilization of neutrophils (a type of white blood cells) towards the area affected by the lesion; neutrophils generate free radicals and this contributes to further damage to cell membranes.
NODOMS+ contains a special ingredient, the subject of many recent studies, capable of counteracting the onset of muscle pain: the Montmorency cherry. The Montmorency sour cherry branded Vitacherry Sport® contains several active ingredients such as polyphenols including flavonoids and type 1 and 2 anthocyanins, which have been shown to have a strong antioxidant activity and to be able to promote a natural anti-inflammatory response. Montmorency sour cherry consumption has been shown to reduce blood concentrations of inflammatory markers and oxidative stress, preventing the triggering of the reactions that lead to muscle damage. The effectiveness of this extract has been highlighted in different types of sports: such as long distance running, cycling, sprinting, football, rugby and strength training. Vitacherry is able to promote muscle recovery and decrease the onset of exercise-induced muscle damage, improving the quality of subsequent training.
In synergy with Vitacherry Sport® NODOMS+ contains VitaGranate®, a pomegranate fruit extract titrated with punicalagin which has a powerful anti-inflammatory and antioxidant action. Scientific literature suggests that the active ingredients in the pomegranate have the function of scavengers of oxidizing species (free radicals) and the ability to selectively inhibit the pro-inflammatory NF-κBtranscription factor , which plays a key role in inducing the inflammatory response. The attenuation of the pro-inflammatory signal or a better ability to eliminate free radicals in skeletal muscle cells can alleviate degenerative muscle damage and improve muscle strength recovery. Some more recent works have also reported that the consumption of polyphenols in untrained subjects has led to an improvement in strength recovery after a single eccentric exercise.
Rednite™ branded beetroot juice is rich in polyphenols, nitrates, vitamin C and E. The latter play a key role in converting nitrates into Nitric Oxide (NO) in our bodies. Nitric oxide is a powerful vasodilator, able to increase the permeability of blood vessels by facilitating the release of substances such as proteins and leukocytes that are involved in the management of the inflammatory process. It also facilitates mitochondria in their function to produce energy, improves blood flow to oxygen and nutrient tissues, optimizing muscle work and recovery. Several studies have shown that the intake of beetroot juice can alleviate the onset of fatigue and muscle pain, increase resistance and tolerance to physical exercise and consequently improve performance.
Finally NODOMS+ contains blackcurrant leaf extract, which, like the other components, has anti-inflammatory and antioxidant properties thanks to all the phytocomplex and some components including quercetin.